5 SIMPLE TECHNIQUES FOR PKRRATING

3B). R526 with the loop in between αJ and αI anchors the C-terminal portion of the activation loop by forming a salt bridge with E458 at The bottom of αEF. Q459 stabilizes the HRD motif by a hydrogen bond to the main chain carbonyl of R413. The idea with the activation segment is stabilized by a hydrogen bond amongst Y454 and E480 from αfile. w

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